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JWH 018 powder for sale is an analytical reference material categorized as a synthetic cannabinoid.1 It is found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

Buy JWH 018 powder online as it is a synthetic cannabinoid containing a replaced indole structure. This indole core is shared with other cannabinoid substances, including PB-22, 5F-PB-22 and AM2201.

It is replaced at R1 with a pentyl chain. The indole core is substituted at R3 with a carbonyl group which is also connected to a naphthalene moiety. It is a bicyclic structure of two fused benzene rings. The carbonyl bridge of it classifies it as a ketone; it is an analog of THJ-018 in which the core indazole structure is replaced with an indole base.

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It affects the function of the brain resulting in the CNS depression. It binds itself to the CB1 receptors dominantly found in the brain. Here is the list of symptoms one would experience are Control of emotions, Motivation, Judgement, memory and learning. Buy JWH-018 for sale

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JWH-018 (1-pentyl-3-(1-naphthoyl)indole or naphthalen-1-yl-(1-pentyl-1H-indol-3-yl)methanone)

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JWH-018 legal status in Germany: JWH-018 is included in Anlage II, which means that is allowed only to trade by the authorized supplier and JWH-018 is not prescriptible.
JWH-018 Canada legal status: JWH-018 is scheduled and included in Schedule II controlled substances list.
JWH-018 Australia legality: JWH-018 is prohibited and included in S9.
JWH-018 US legal status: JWH-018 is scheduled and included in the list of Schedule I controlled substances.

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IUPAC Name: 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone
Other Names: JWH-210
Cas Number: 824959-81-1
Molecular Formula: C26H27NO
Molar Mass: 369.498 g/mol
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder

Product Name: JWH-250
IUPAC Name: 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Other Names:
Cas Number: 864445-43-2
Molecular Formula: C22H25NO2
Molar Mass: 335.439 g/mol
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder

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JWH-250 legal status in the USA: JWH-250 is a scheduled designer drug and is included in the list of Schedule I controlled substances.
JWH-250 Canada legality: it is scheduled and included in Schedule II
JWH-250 legal status in Germany: JWH-250 is included in Anlage II list of controlled substances.
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Legislation Status

Starting from 2009, different European countries subjected all products containing synthetic cannabinoids to the narcotics laws, preventing their sale in head shops and online stores (Fattore & Fratta, 2011; Seely et al., 2012). In 2011, JWH-018, JWH-073, JWH-200, CP-47,497, and (C8)-CP-47,497 were classified as Schedule I of the Controlled Substances Act, and 177 different synthetic cannabinoids were reported in 2014 to the United Nations Office on drugs and crime early warning advisory from 58 different countries and territories (UNODC, 2015). At present (2016), current legislations are adopting a more general approach by providing a broader definition of regulated compounds to target entire classes of substances derived from a certain chemical structure rather than specific molecules. Buy JWH-018 for sale

Synthetic cannabinoids (SC)*

Martin F. Casey, Alex F. Manini, in Novel Psychoactive Substances (Second Edition), 2022

Animal data

In a rat discrimination study, where rats were initially trained to discriminate THC from vehicle, SCs such as CP-55,940 and WIN-55,212–2 were able to substitute for THC . These effects could be attenuated by the effects of the CB₁ antagonist SR-141,716A. Buy JWH-018 for sale

In a rhesus monkey model, animals were trained to discriminate THC, JWH-018, JWH-073 from vehicle in drug lever pressing studies . The ED₅₀ values were 0.044, 0.013, 0.058 mg/kg and duration of action was four, two and one hour for THC, JWH-018 and JWH-073, respectively. All three compounds could dose-dependently attenuate the rimonabant (CB₁ receptor antagonist) discriminative stimulus in animals chronically treated with THC. The authors of this study concluded that the SCs (JWH-018 and JWH-073) had similar subjective effects to THC, and furthermore postulated that the shorter duration of action may lead to more frequent use and, in turn, increased dependence. Buy JWH-018 for sale

In another rhesus monkey study, animals were given either three or 14 days of pre-treatment with THC to study its effects on tolerance to three SCs (CP-55,940; JWH-073; JWH-018) [203]. Three days of pre-treatment with THC did not result in cross tolerance to any of these three SC compounds. Fourteen days pre-treatment with THC decreased sensitivity to THC, CP-55,940, JWH-018 and JWH-073 9.2-fold, 3.6-fold, 4.3-fold and 5.6-fold respectively. The differences in sensitivity to pre-treatment with THC may indicate differences in the potential for dependence associated with THC and SC and also between different SC. Buy JWH-018 for sale

Substance Misuse: Legal Highs

M. Scott-Ham, M.M. Stark, in Encyclopedia of Forensic and Legal Medicine (Second Edition), 2016

Synthetic Cannabinoids

These substances, synthetic cannabinoid receptor agonists, contain synthetic chemicals, often mixed with herbal mixtures, which mimic the main psychoactive compound of cannabis, Δ⁹-tetrahydrocannabinol (THC), binding to the same cannabinoid receptors (CB1 and CB2) in the brain and elsewhere in the body. However, often these substances are many more powerful than THC found in natural cannabis. For example, JWH-018 is approximately 4 times more potent than THC, and JWH-210 is 90 times more potent. Buy JWH-018 for sale

The synthetic cannabinoid JWH-018 was first detected in Spice products in 2008 and as of May 2013 84 synthetic cannabinoids have been notified to the EMCDDA (EMCDDA, 2013a,b). This is the largest group of chemicals monitored by the EU EWS. JWH-018 is a naphthoylindole, belonging to the aminoalkylindole family, having different chemical structure to THC but similar, more potent, effects. JWH compounds are named after John W. Huffman, the scientist who first synthesized these cannabinoids; AM compounds are named after Alexandros Makriyannis; HU are named after the Hebrew University Jerusalem where they were developed. More than one synthetic cannabinoid may be present in preparations sold. Buy JWH-018 for sale

The drugs are smoked, often with tobacco, with effects including mood elevation, relaxation, and perceptual disturbances. Other effects include chest pain, drowsiness, increase in pulse and blood pressure, dilated pupils, nausea and vomiting, and seizures. Anxiety, psychosis, hallucinations, paranoid delusions, insomnia and suicidal ideation, as well as cognitive impairment, confusion, disorientation, and effects on memory have been reported (Hermanns-Clausen et al., 2013; Seeley et al., 2012). Reemergence of psychotic symptoms may occur as well as new-onset psychosis and the protracted presence of psychotic symptoms beyond acute intoxication has been reported and is concerning Buy JWH-018 for sale

Synthetic Cannabinoid Receptor Agonists (Spice) as New Recreational Psychoactive Substances

A. Helander, in Handbook of Cannabis and Related Pathologies, 2017

Effect of legislation of synthetic cannabinoids

Already by the end of Jan. 2009, JWH-018 and CP-47,497-C8 were banned in Germany, due to reports of intoxication, abuse, and health problems associated with chronic use of Spice Nevertheless, already a few months later, it was demonstrated that JWH-018 had been replaced in Spice products by one of its “legal” structural analogs, JWH-073 Buy JWH-018 for sale

This represented the start of an ongoing “cat-and-mouse game,” where the psychoactive additives in herbal smoking mixtures made illegal are rapidly removed and replaced with novel, similar synthetic cannabinoids (ie, “designer drugs”) that are ready in the pipeline, to maintain the legal standing of the products (ie, “legal highs”) (Helander, Bäckberg, Hultén, Al-Saffar, & Beck, 2014). Consequently, partly due to legislative actions undertaken in the European countries, the number of “new psychoactive substances” (NPS) noted by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) has increased dramatically in the last years (EMCDDA, 2014). Of all NPS identified, synthetic cannabinoids make up an essential part (ie, 27–47% each year since 2009), totally counting to more than 100 during the period 2008–2013. Buy JWH-018 for sale

Synthetic drugs of abuse

Kenichi Tamama, in Advances in Clinical Chemistry, 2021

2.4 Regulatory status of synthetic cannabinoids

Synthetic cannabinoids have no accepted medical use in the US. The US Drug Enforcement Administration (DEA) classified five synthetic cannabinoids (JWH-018, JWH-073, JWH-200, CP-47,497, and CP-47,497 C8 homolog) under temporary Schedule I of the Controlled Substances Act (CSA) on March 2011 . In July 2012, the U.S. Government passed the Synthetic Drug Abuse Prevention Act (SDAPA), which defined 15 synthetic cannabinoids (CP-47,497, CP-47,497 C8-homolog, JWH-018, JWH-073 JWH-019, JWH-200, JWH-250, JWH-081, JWH-122, JWH-398, AM2201, AM694, SR-19, SR-18, and JWH-203) as cannabimimetic agents and placed these compounds into controlled substances Schedule I . Furthermore, FUB-AMB, 5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA, and MDMB-FUBINACA were emergency scheduled as Schedule I controlled substances by DEA in 2017 Additionally, five synthetic cannabinoids, including FUB-AKB48, were placed under temporary Schedule I of the CSA in April 2019 Buy JWH-018 for sale

Other synthetic cannabinoids may be subject to prosecution under the Controlled Substance Analogue Enforcement Act, which covers any compounds that are not formally controlled substances, but structurally or pharmacologically similar to Schedule I or II controlled substances without any legitimate medical use .

Synthetic cannabinoids have also been scheduled in EU countries These compounds were not included in the original list of the scheduled psychoactive substances by the Convention on Psychotropic Substances of 1971, but the synthetic cannabinoids have been added to the list of the scheduled psychoactive substances by the Convention Buy JWH-018 for sale

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Synthetic cannabinoids (SC)*

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Synthetic Cannabinoids

Synthetic Cannabinoid Receptor Agonists (Spice) as New Recreational Psychoactive Substances

Effect of legislation of synthetic cannabinoids

Synthetic drugs of abuse

2.4 Regulatory status of synthetic cannabinoids

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